CMap Candidate Details

Structure:
CMap ID: C13960
Pert ID: BRD-K36386086
Compound Name: dolutegravir
Targets: CYP3A7; CYP3A4; CYP3A5; POU2F2; UGT1A1
MoA: HIV integrase inhibitor
SMILES: C[C@H]1CCO[C@H]2Cn3cc(C(=O)NCc4ccc(F)cc4F)c(=O)c(O)c3C(=O)N12
InchiKey: RHWKPHLQXYSBKR-BONVTDFDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120536 BRD-K36386086 A375 3.33 uM 24 h -0.2 -0.84 0.01 0.39 1.39 2.17
120582 BRD-K36386086 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120639 BRD-K36386086 HELA 3.33 uM 3 h 0.22 0.93 0.05 0.0 0.0 0.0
120687 BRD-K36386086 HT29 10 uM 24 h -0.15 -0.6 0.0 0.2 0.71 0.02
120741 BRD-K36386086 JURKAT 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120794 BRD-K36386086 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120849 BRD-K36386086 YAPC 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129016 BRD-K36386086 HA1E 0.25 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
129073 BRD-K36386086 MCF??7.00 0.25 uM 24 h 0.0 0.0 0.0 0.26 0.92 0.25
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).