CMap Candidate Details

Structure:
CMap ID: C01398
Pert ID: BRD-A58767537
Compound Name: afatinib
Targets: EGFR; ERBB2; ERBB4
MoA: EGFR inhibitor
SMILES: CN(C)CC=CC(=O)Nc1cc2c(Nc3ccc(F)c(Cl)c3)ncnc2cc1OC1CCOC1
InchiKey: ULXXDDBFHOBEHA-ONEGZZNKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90790 BRD-A58767537 HPTEC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91872 BRD-A58767537 MCF??7.00 10 uM 6 h 0.25 1.02 0.13 0.0 0.0 0.0
91907 BRD-A58767537 MDAMB231 10 uM 6 h 0.0 0.0 0.0 0.32 1.13 0.85
92408 BRD-A58767537 A375 0.04 uM 24 h 0.0 0.0 0.0 -0.22 -0.74 0.05
92433 BRD-A58767537 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92463 BRD-A58767537 BT20 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92499 BRD-A58767537 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92533 BRD-A58767537 HME1 10 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
92607 BRD-A58767537 HS578T 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
92629 BRD-A58767537 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92667 BRD-A58767537 LNCAP 10 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.92
92733 BRD-A58767537 MCF10A 0.12 uM 3 h 0.0 0.0 0.0 0.32 1.12 0.78
92805 BRD-A58767537 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92851 BRD-A58767537 SKBR3 10 uM 3 h 0.0 0.0 0.0 0.25 0.89 0.21
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).