CMap Candidate Details

Structure:
CMap ID: C14017
Pert ID: BRD-K36616567
Compound Name: doxepin
Targets: HRH1; HRH2; SLC6A2; SLC6A4
MoA: Histamine receptor antagonist
SMILES: CN(C)CCC=C1c2ccccc2COc3ccccc13
InchiKey: ODQWQRRAPPTVAG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5446 BRD-K36616567 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5770 BRD-K36616567 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6182 BRD-K36616567 PC3 10 uM 24 h 0.0 0.0 0.0 -0.3 -0.99 0.51
6402 BRD-K36616567 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44378 BRD-K36616567 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44697 BRD-K36616567 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44940 BRD-K36616567 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45238 BRD-K36616567 HEPG2 10 uM 6 h -0.3 -1.26 0.72 0.27 0.96 0.34
45508 BRD-K36616567 HT29 10 uM 6 h -0.3 -1.25 0.7 0.0 0.0 0.0
46059 BRD-K36616567 NPC 10 uM 24 h 0.34 1.43 1.12 0.0 0.0 0.0
46375 BRD-K36616567 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46695 BRD-K36616567 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
51302 BRD-K36616567 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).