CMap Candidate Details

Structure:
CMap ID: C14045
Pert ID: BRD-K36680103
Compound Name: omecamtiv-mecarbil
Targets: MYBPC3
MoA: Cardiac myosin activator; Unidentified pharmacological activity
SMILES: COC(=O)N1CCN(Cc2cccc(NC(=O)Nc3ccc(C)nc3)c2F)CC1
InchiKey: RFUBTTPMWSKEIW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
120580 BRD-K36680103 A549 0.37 uM 24 h 0.0 0.0 0.0 0.28 1.0 0.42
120609 BRD-K36680103 HA1E 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120685 BRD-K36680103 HT29 10 uM 24 h 0.23 0.97 0.08 -0.3 -1.0 0.54
120739 BRD-K36680103 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.54
120792 BRD-K36680103 PC3 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
120847 BRD-K36680103 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
128998 BRD-K36680103 A375 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129044 BRD-K36680103 HELA 0.01 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
129072 BRD-K36680103 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).