CMap Candidate Details

Structure:
CMap ID: C14067
Pert ID: BRD-K36737713
Compound Name: AG-957
Targets: EGFR; ABL1
MoA: Protein tyrosine kinase inhibitor
SMILES: COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1
InchiKey: QSFREBZMBNRGOK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5203 BRD-K36737713 A375 10 uM 6 h -0.24 -1.0 0.15 0.46 1.61 2.39
5447 BRD-K36737713 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5616 BRD-K36737713 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6183 BRD-K36737713 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6539 BRD-K36737713 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39321 BRD-K36737713 A549 10 uM 24 h -0.2 -0.84 0.0 -0.27 -0.91 0.3
39684 BRD-K36737713 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40617 BRD-K36737713 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.95 0.39
40802 BRD-K36737713 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41106 BRD-K36737713 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41439 BRD-K36737713 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119659 BRD-K36737713 HEPG2 10 uM 24 h -0.16 -0.66 0.0 0.0 0.0 0.0
119697 BRD-K36737713 HT29 10 uM 24 h 0.32 1.33 0.86 0.37 1.3 1.49
119744 BRD-K36737713 JURKAT 3.33 uM 24 h -0.29 -1.19 0.54 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).