CMap Candidate Details

Structure:
CMap ID: C14113
Pert ID: BRD-K36862742
Compound Name: hydroflumethiazide
Targets: SLC12A1
MoA: Sodium/potassium/chloride transporter inhibitor
SMILES: NS(=O)(=O)c1cc2c(NCNS2(=O)=O)cc1C(F)(F)F
InchiKey: DMDGGSIALPNSEE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
50003 BRD-K36862742 A549 10 uM 6 h 0.0 0.0 0.0 -0.3 -1.0 0.55
50355 BRD-K36862742 HCC515 10 uM 6 h -0.18 -0.74 0.0 0.0 0.0 0.0
51028 BRD-K36862742 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121732 BRD-K36862742 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121756 BRD-K36862742 HELA 1.11 uM 24 h 0.0 0.0 0.0 -0.32 -1.07 0.76
121786 BRD-K36862742 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121836 BRD-K36862742 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129750 BRD-K36862742 A375 0.25 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.1
129815 BRD-K36862742 HEK293 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129910 BRD-K36862742 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129942 BRD-K36862742 MCF10A 0.25 uM 24 h -0.2 -0.84 0.0 -0.34 -1.15 1.07
129991 BRD-K36862742 MCF??7.00 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130026 BRD-K36862742 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130098 BRD-K36862742 THP1 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130149 BRD-K36862742 YAPC 0.08 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).