CMap Candidate Details

Structure:
CMap ID: C14129
Pert ID: BRD-K36927236
Compound Name: glibenclamide
Targets: CFTR; KCNJ5; KCNJ8; KCNJ11; ABCC8
MoA: Sulfonylurea; ATP channel blocker; Insulin secretagogue
SMILES: COc1ccc(Cl)cc1C(=O)NCCc2ccc(cc2)S(=O)(=O)NC(=O)NC3CCCCC3
InchiKey: ZNNLBTZKUZBEKO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3780 BRD-K36927236 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
9416 BRD-K36927236 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9724 BRD-K36927236 H1299 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10282 BRD-K36927236 HCC515 10 uM 6 h 0.3 1.24 0.52 -0.22 -0.73 0.05
10510 BRD-K36927236 HCT116 10 uM 6 h -0.22 -0.9 0.05 -0.27 -0.91 0.3
11479 BRD-K36927236 NCIH2073 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.96 0.44
11757 BRD-K36927236 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12043 BRD-K36927236 NCIH596 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12308 BRD-K36927236 NOMO1 10 uM 6 h -0.23 -0.97 0.11 0.0 0.0 0.0
12785 BRD-K36927236 SW480 10 uM 6 h -0.19 -0.81 0.0 0.0 0.0 0.0
12985 BRD-K36927236 THP1 10 uM 6 h 0.0 0.0 0.0 0.18 0.63 0.0
13266 BRD-K36927236 U937 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.04 0.68
39685 BRD-K36927236 ASC 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.7
40803 BRD-K36927236 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41440 BRD-K36927236 SKB 10 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
99893 BRD-K36927236 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
116990 BRD-K36927236 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117029 BRD-K36927236 A549 10 uM 24 h 0.22 0.9 0.03 0.21 0.75 0.04
117071 BRD-K36927236 HA1E 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117157 BRD-K36927236 HEPG2 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
117201 BRD-K36927236 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
121864 BRD-K36927236 YAPC 3.33 uM 24 h 0.2 0.83 0.0 -0.34 -1.16 1.11
129813 BRD-K36927236 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129865 BRD-K36927236 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
129909 BRD-K36927236 JURKAT 0.74 uM 24 h -0.28 -1.15 0.44 0.0 0.0 0.0
129940 BRD-K36927236 MCF10A 0.03 uM 24 h 0.21 0.89 0.02 0.0 0.0 0.0
129989 BRD-K36927236 MCF??7.00 0.03 uM 24 h -0.26 -1.09 0.33 0.27 0.94 0.29
130024 BRD-K36927236 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
130076 BRD-K36927236 PC3 2.22 uM 24 h 0.25 1.02 0.13 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).