CMap Candidate Details

Structure:
CMap ID: C01414
Pert ID: BRD-A59215453
Compound Name: lobelanidine
Targets: OPRM1; SLC18A2
MoA: Opioid receptor antagonist; Dopamine receptor modulator; Acetylcholine receptor antagonist; Vesicular monoamine transporter ligand
SMILES: CN1C(CC(O)c2ccccc2)CCCC1CC(O)c3ccccc3
InchiKey: OWGJQNXIWMMDTH-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1504 BRD-A59215453 HA1E 10 uM 24 h -0.24 -0.99 0.13 -0.32 -1.07 0.75
1835 BRD-A59215453 HCC515 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.68
2295 BRD-A59215453 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
2783 BRD-A59215453 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42022 BRD-A59215453 A549 10 uM 6 h 0.0 0.0 0.0 0.26 0.92 0.25
42221 BRD-A59215453 ASC 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.03
42563 BRD-A59215453 HEPG2 10 uM 6 h -0.24 -1.02 0.17 0.22 0.79 0.07
42870 BRD-A59215453 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43132 BRD-A59215453 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
43422 BRD-A59215453 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44018 BRD-A59215453 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100242 BRD-A59215453 U2OS 4 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).