CMap Candidate Details

Structure:
CMap ID: C14180
Pert ID: BRD-K37080523
Compound Name: isoreserpine
Targets: SLC18A1; SLC18A2
MoA: Vesicular monoamine transporter inhibitor
SMILES: CO[C@H]1[C@@H](C[C@@H]2CN3CCc4c([nH]c5cc(OC)ccc45)[C@@H]3C[C@@H]2[C@@H]1C(=O)OC)OC(=O)c6cc(OC)c(OC)c(OC)c6
InchiKey: QEVHRUUCFGRFIF-VPHNHGCZSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3013 BRD-K37080523 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3188 BRD-K37080523 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3493 BRD-K37080523 PC3 10 uM 24 h 0.26 1.07 0.2 -0.25 -0.83 0.16
3782 BRD-K37080523 VCAP 10 uM 24 h -0.24 -1.0 0.14 0.27 0.95 0.31
42093 BRD-K37080523 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42356 BRD-K37080523 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42682 BRD-K37080523 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.34 1.2 1.07
42986 BRD-K37080523 HT29 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.38
43316 BRD-K37080523 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.37 1.32 1.61
43547 BRD-K37080523 NPC 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.69
43845 BRD-K37080523 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44112 BRD-K37080523 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).