CMap Candidate Details

Structure:
CMap ID: C01425
Pert ID: BRD-A59808129
Compound Name: guggulsterone
Targets: NR3C1; AR; NR3C2; PGR; NR1H4
MoA: IKK inhibitor; FXR antagonist; Cholesterol inhibitor; Estrogen receptor agonist; Pregnane X receptor agonist; Progesterone receptor agonist
SMILES: CC=C1/C(=O)CC2C3CCC4=CC(=O)CC[C@@]4(C)C3CC[C@@]12C
InchiKey: WDXRGPWQVHZTQJ-SXMNTYMYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33881 BRD-A59808129 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
33998 BRD-A59808129 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34275 BRD-A59808129 HA1E 10 uM 6 h 0.26 1.08 0.22 0.0 0.0 0.0
34512 BRD-A59808129 HCC515 10 uM 6 h 0.0 0.0 0.0 0.25 0.9 0.22
34781 BRD-A59808129 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35055 BRD-A59808129 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35273 BRD-A59808129 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
35693 BRD-A59808129 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
36155 BRD-A59808129 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36450 BRD-A59808129 SKB 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
36934 BRD-A59808129 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
96310 BRD-A59808129 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96381 BRD-A59808129 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.74
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).