CMap Candidate Details

Structure:
CMap ID: C14262
Pert ID: BRD-K37289225
Compound Name: clozapine
Targets: CHRM1; CHRM2; CHRM3; CHRM4; ADRA1B; ADRA1A; DRD1; DRD2; DRD3; DRD4; HRH1; HTR1A; HTR1B; HTR1D; HTR1E; HTR2A; HTR2C; HTR6; HTR7; HRH4
MoA: Dopamine receptor antagonist; Serotonin receptor antagonist
SMILES: CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
InchiKey: QZUDBNBUXVUHMW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1450 BRD-K37289225 NPC 25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3190 BRD-K37289225 HCC515 10 uM 24 h 0.25 1.05 0.17 0.32 1.14 0.87
3783 BRD-K37289225 VCAP 10 uM 24 h -0.31 -1.3 0.82 0.27 0.96 0.34
42357 BRD-K37289225 ASC 10 uM 24 h 0.17 0.71 0.0 0.0 0.0 0.0
42683 BRD-K37289225 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.38 1.33 1.72
43317 BRD-K37289225 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44113 BRD-K37289225 SKB 10 uM 24 h 0.25 1.05 0.18 0.0 0.0 0.0
91111 BRD-K37289225 HUH7 10 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
98377 BRD-K37289225 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99898 BRD-K37289225 U2OS 15 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
123268 BRD-K37289225 HA1E 0.04 uM 24 h 0.2 0.82 0.0 0.0 0.0 0.0
123299 BRD-K37289225 HELA 1.11 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
123328 BRD-K37289225 HT29 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123358 BRD-K37289225 MCF10A 1.11 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
123386 BRD-K37289225 MDAMB231 0.37 uM 24 h 0.0 0.0 0.0 -0.38 -1.3 1.57
123408 BRD-K37289225 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123477 BRD-K37289225 YAPC 10 uM 24 h 0.0 0.0 0.0 0.37 1.31 1.59
131520 BRD-K37289225 A375 0.08 uM 24 h 0.32 1.33 0.85 0.0 0.0 0.0
131536 BRD-K37289225 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131606 BRD-K37289225 HEK293 0.01 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.05
131699 BRD-K37289225 HUVEC 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131752 BRD-K37289225 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131923 BRD-K37289225 THP1 0.01 uM 24 h 0.0 0.0 0.0 -0.3 -1.0 0.55
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).