CMap Candidate Details

Structure:
CMap ID: C14273
Pert ID: BRD-K37312348
Compound Name: kenpaullone
Targets: CDK5; GSK3B; CDK1
MoA: CDK inhibitor; GSK-3 inhibitor
SMILES: Brc1ccc2[nH]c-3c(CC(=O)Nc4ccccc-34)c2c1
InchiKey: QQUXFYAWXPMDOE-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2877 BRD-K37312348 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3361 BRD-K37312348 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
3494 BRD-K37312348 PC3 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
3784 BRD-K37312348 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.86 0.22
39686 BRD-K37312348 ASC 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.25
40467 BRD-K37312348 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.99
41441 BRD-K37312348 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
53395 BRD-K37312348 HEPG2 4 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
53509 BRD-K37312348 HUH7 4 uM 24 h 0.0 0.0 0.0 -0.25 -0.83 0.16
53657 BRD-K37312348 PHH 15 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96138 BRD-K37312348 A549 10 uM 24 h -0.26 -1.07 0.28 -0.27 -0.92 0.33
97022 BRD-K37312348 A375 10 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.14
99033 BRD-K37312348 NEU 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99143 BRD-K37312348 NPC 10 uM 24 h 0.22 0.91 0.03 0.0 0.0 0.0
116159 BRD-K37312348 HT29 15 uM 24 h 0.0 0.0 0.0 -0.23 -0.76 0.07
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).