CMap Candidate Details

Structure:
CMap ID: C01428
Pert ID: BRD-A59985574
Compound Name: topotecan
Targets: TOP1
MoA: Topoisomerase inhibitor
SMILES: CCC1(O)C(=O)OCc2c1cc1-c3nc4ccc(O)c(CN(C)C)c4cc3Cn1c2=O
InchiKey: UCFGDBYHRUNTLO-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25623 BRD-A59985574 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
26042 BRD-A59985574 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
26208 BRD-A59985574 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
26552 BRD-A59985574 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
26868 BRD-A59985574 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27171 BRD-A59985574 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27656 BRD-A59985574 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
27798 BRD-A59985574 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28108 BRD-A59985574 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28420 BRD-A59985574 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
28746 BRD-A59985574 PHH 10 uM 24 h 0.22 0.93 0.04 0.0 0.0 0.0
29059 BRD-A59985574 SKB 10 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.49
29393 BRD-A59985574 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
90898 BRD-A59985574 MCF10A 1.11 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).