CMap Candidate Details

Structure:
CMap ID: C14296
Pert ID: BRD-K37385792
Compound Name: conivaptan
Targets: AVPR1A; AVPR2
MoA: Vasopressin receptor antagonist
SMILES: Cc1nc2CCN(C(=O)c3ccc(NC(=O)c4ccccc4-c4ccccc4)cc3)c3ccccc3-c2[nH]1
InchiKey: IKENVDNFQMCRTR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96624 BRD-K37385792 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123256 BRD-K37385792 A549 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123269 BRD-K37385792 HA1E 10 uM 24 h 0.24 0.99 0.1 0.23 0.81 0.09
123329 BRD-K37385792 HT29 10 uM 24 h 0.18 0.75 0.0 0.0 0.0 0.0
123387 BRD-K37385792 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123409 BRD-K37385792 PC3 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123444 BRD-K37385792 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123478 BRD-K37385792 YAPC 10 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.49
131607 BRD-K37385792 HEK293 0.74 uM 24 h -0.22 -0.94 0.07 0.19 0.66 0.01
131648 BRD-K37385792 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131700 BRD-K37385792 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131753 BRD-K37385792 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131808 BRD-K37385792 MCF10A 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131837 BRD-K37385792 MCF??7.00 0.01 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.39
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).