CMap Candidate Details

Structure:
CMap ID: C01431
Pert ID: BRD-A60070924
Compound Name: alpha-estradiol
Targets: ESR1; ESR2; NR1I2
MoA: Estrogen receptor agonist
SMILES: CC12CCC3C(CCc4cc(O)ccc34)C1CCC2O
InchiKey: VOXZDWNPVJITMN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1136 BRD-A60070924 PC3 2.22 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
88144 BRD-A60070924 VCAP 20 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
99933 BRD-A60070924 U2OS 20 uM 6 h -0.24 -1.0 0.15 0.2 0.7 0.01
119167 BRD-A60070924 A375 0.12 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
119198 BRD-A60070924 A549 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
119224 BRD-A60070924 HA1E 0.04 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.65
119253 BRD-A60070924 HCC515 0.12 uM 24 h 0.27 1.14 0.31 0.0 0.0 0.0
119284 BRD-A60070924 HEPG2 10 uM 24 h 0.0 0.0 0.0 -0.23 -0.77 0.08
119312 BRD-A60070924 HT29 0.37 uM 24 h -0.29 -1.21 0.58 -0.29 -0.97 0.45
119338 BRD-A60070924 MCF??7.00 10 uM 24 h 0.29 1.2 0.43 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).