CMap Candidate Details

Structure:
CMap ID: C01436
Pert ID: BRD-A60245366
Compound Name: AS-601245
Targets: MAPK8; MAPK9; MAPK10
MoA: JNK inhibitor
SMILES: N#CC(c1nc2ccccc2s1)c1ccnc(NCCc2cccnc2)n1
InchiKey: RCYPVQCPYKNSTG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33752 BRD-A60245366 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
33999 BRD-A60245366 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34276 BRD-A60245366 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
34782 BRD-A60245366 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
36156 BRD-A60245366 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36451 BRD-A60245366 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36935 BRD-A60245366 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91740 BRD-A60245366 SKBR3 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92035 BRD-A60245366 BT20 1.11 uM 24 h -0.22 -0.91 0.05 0.0 0.0 0.0
92118 BRD-A60245366 HCC515 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92150 BRD-A60245366 HS578T 0.37 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.46
92202 BRD-A60245366 HT29 3.33 uM 24 h -0.17 -0.69 0.0 -0.21 -0.69 0.02
92224 BRD-A60245366 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92264 BRD-A60245366 MCF??7.00 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92300 BRD-A60245366 MDAMB231 0.37 uM 24 h -0.22 -0.91 0.05 0.32 1.12 0.77
92355 BRD-A60245366 PC3 3.33 uM 24 h -0.28 -1.17 0.49 0.0 0.0 0.0
97267 BRD-A60245366 HAP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97349 BRD-A60245366 A375 3.33 uM 24 h 0.25 1.03 0.14 0.26 0.92 0.24
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).