CMap Candidate Details

Structure:
CMap ID: C01438
Pert ID: BRD-A60274948
Compound Name: bromocriptine
Targets: ADRA2A; ADRA2B; ADRA2C; DRD1; DRD2; DRD3; DRD4; DRD5; HTR1A; HTR1B; HTR1D; HTR2A; HTR2B; HTR2C
MoA: Dopamine receptor agonist
SMILES: CC(C)C[C@@H]1N2C(=O)[C@](NC(=O)[C@H]3CN(C)C4Cc5c(Br)[nH]c6cccc(C4=C3)c56)(O[C@@]2(O)[C@@H]7CCCN7C1=O)C(C)C
InchiKey: OZVBMTJYIDMWIL-BGNMTYTCSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6848 BRD-A60274948 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7095 BRD-A60274948 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7401 BRD-A60274948 HA1E 10 uM 6 h -0.21 -0.86 0.02 -0.3 -1.0 0.52
7566 BRD-A60274948 HCC515 10 uM 6 h 0.0 0.0 0.0 0.2 0.7 0.02
7961 BRD-A60274948 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
8053 BRD-A60274948 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8316 BRD-A60274948 PC3 10 uM 24 h 0.0 0.0 0.0 0.22 0.8 0.08
8600 BRD-A60274948 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.06 0.73
91109 BRD-A60274948 HUH7 4 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).