CMap Candidate Details

Structure:
CMap ID: C00144
Pert ID: BRD-A05680309
Compound Name: BRD-A05680309
Targets: XIAP; CASP8
MoA: XIAP inhibitor; Caspase activator
SMILES: CNC(C)C(=O)NC(C(C)C)C(=O)N1CCCC1C(=O)NC2CCCc3ccccc23
InchiKey: POKZVJVCUGVHME-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
13718 BRD-A05680309 A375 10 uM 24 h -0.2 -0.81 0.0 -0.37 -1.23 1.28
14186 BRD-A05680309 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
14561 BRD-A05680309 HA1E 10 uM 6 h 0.24 1.0 0.11 -0.29 -0.97 0.46
14699 BRD-A05680309 HCC515 10 uM 6 h 0.22 0.93 0.05 -0.32 -1.08 0.81
15179 BRD-A05680309 HT29 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.86
15254 BRD-A05680309 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.3 1.05 0.57
15696 BRD-A05680309 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
15995 BRD-A05680309 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).