CMap Candidate Details

Structure:
CMap ID: C14406
Pert ID: BRD-K37694030
Compound Name: doxepin
Targets: HRH1; HRH2; SLC6A2; SLC6A4
MoA: Histamine receptor antagonist
SMILES: CN(C)CCC=C1c2ccccc2COc2ccccc12
InchiKey: ODQWQRRAPPTVAG-BOPFTXTBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5448 BRD-K37694030 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5771 BRD-K37694030 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6185 BRD-K37694030 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
25362 BRD-K37694030 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41931 BRD-K37694030 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42358 BRD-K37694030 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42684 BRD-K37694030 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43548 BRD-K37694030 NPC 10 uM 24 h 0.32 1.35 0.96 0.0 0.0 0.0
43846 BRD-K37694030 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44114 BRD-K37694030 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123595 BRD-K37694030 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123710 BRD-K37694030 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123732 BRD-K37694030 MCF??7.00 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123776 BRD-K37694030 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131996 BRD-K37694030 A375 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132047 BRD-K37694030 HELA 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132065 BRD-K37694030 HT29 0.01 uM 24 h 0.29 1.21 0.47 -0.4 -1.34 1.86
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).