CMap Candidate Details

Structure:
CMap ID: C01442
Pert ID: BRD-A60414806
Compound Name: vincristine
Targets: TUBB
MoA: Tubulin inhibitor
SMILES: CC[C@]1(O)CC2CN(C1)CCc1c([nH]c3ccccc13)[C@@](C2)(C(=O)OC)c1cc2c(cc1OC)N(C=O)[C@@H]1[C@]22CCN3CC=C[C@](CC)([C@@H]23)[C@@H](OC(C)=O)[C@]1(O)C(=O)OC
InchiKey: OGWKCGZFUXNPDA-CUGARIAGSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4176 BRD-A60414806 HA1E 10 uM 6 h -0.25 -1.02 0.18 -0.38 -1.29 1.49
4315 BRD-A60414806 HCC515 10 uM 24 h 0.0 0.0 0.0 0.24 0.86 0.16
4622 BRD-A60414806 PC3 10 uM 24 h -0.26 -1.07 0.26 -0.42 -1.41 2.02
4860 BRD-A60414806 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37090 BRD-A60414806 A375 10 uM 6 h -0.22 -0.93 0.07 0.0 0.0 0.0
37245 BRD-A60414806 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37527 BRD-A60414806 ASC 10 uM 24 h 0.24 0.99 0.1 -0.26 -0.89 0.26
37836 BRD-A60414806 HEPG2 10 uM 6 h 0.19 0.78 0.0 0.0 0.0 0.0
38026 BRD-A60414806 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38158 BRD-A60414806 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38374 BRD-A60414806 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).