CMap Candidate Details

Structure:
CMap ID: C14447
Pert ID: BRD-K37798499
Compound Name: etoposide
Targets: TOP2A; TOP2B
MoA: Topoisomerase inhibitor
SMILES: COc1cc(cc(OC)c1O)[C@H]1[C@@H]2[C@H](COC2=O)[C@H](O[C@@H]2O[C@@H]3CO[C@@H](C)O[C@H]3[C@H](O)[C@H]2O)c2cc3OCOc3cc12
InchiKey: VJJPUSNTGOMMGY-MRVIYFEKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
24575 BRD-K37798499 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
24767 BRD-K37798499 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.33 -1.1 0.88
25506 BRD-K37798499 VCAP 10 uM 6 h 0.0 0.0 0.0 -0.36 -1.23 1.25
90999 BRD-K37798499 HUH7 6.66 uM 72 h 0.0 0.0 0.0 0.0 0.0 0.0
95808 BRD-K37798499 NPC 4 uM 6 h -0.23 -0.94 0.08 0.0 0.0 0.0
95919 BRD-K37798499 YAPC 4 uM 6 h 0.0 0.0 0.0 -0.28 -0.96 0.42
95959 BRD-K37798499 MCF10A 0.3 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99905 BRD-K37798499 U2OS 3.33 uM 6 h 0.23 0.94 0.06 0.0 0.0 0.0
115270 BRD-K37798499 A375 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115415 BRD-K37798499 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115466 BRD-K37798499 HEPG2 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115517 BRD-K37798499 HT29 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
115566 BRD-K37798499 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
115613 BRD-K37798499 PC3 10 uM 24 h 0.28 1.17 0.36 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).