CMap Candidate Details

Structure:
CMap ID: C14472
Pert ID: BRD-K37872686
Compound Name: tirofiban
Targets: ITGA2B; ITGB3
MoA: Platelet aggregation inhibitor; Structural glycoprotein antagonist
SMILES: CCCCS(=O)(=O)N[C@@H](Cc1ccc(OCCCCC2CCNCC2)cc1)C(O)=O
InchiKey: COKMIXFXJJXBQG-NRFANRHFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123260 BRD-K37872686 A549 1.11 uM 24 h 0.0 0.0 0.0 0.24 0.85 0.15
123304 BRD-K37872686 HELA 3.33 uM 24 h 0.3 1.25 0.54 -0.29 -0.99 0.5
123390 BRD-K37872686 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123448 BRD-K37872686 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123482 BRD-K37872686 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131523 BRD-K37872686 A375 2.22 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
131575 BRD-K37872686 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131613 BRD-K37872686 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131677 BRD-K37872686 HT29 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131706 BRD-K37872686 HUVEC 0.74 uM 24 h -0.21 -0.85 0.01 0.27 0.96 0.34
131759 BRD-K37872686 JURKAT 2.22 uM 24 h 0.28 1.19 0.41 0.33 1.16 0.91
131813 BRD-K37872686 MCF10A 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131843 BRD-K37872686 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131912 BRD-K37872686 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).