CMap Candidate Details

Structure:
CMap ID: C14511
Pert ID: BRD-K37991163
Compound Name: paroxetine
Targets: SLC6A4
MoA: Selective serotonin reuptake inhibitor
SMILES: Fc1ccc(cc1)[C@@H]1CCNC[C@H]1COc1ccc2OCOc2c1
InchiKey: AHOUBRCZNHFOSL-YOEHRIQHSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5772 BRD-K37991163 HCC515 10 uM 6 h 0.0 0.0 0.0 0.28 0.99 0.41
6186 BRD-K37991163 PC3 10 uM 24 h 0.19 0.79 0.0 0.31 1.11 0.73
6541 BRD-K37991163 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
24768 BRD-K37991163 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37149 BRD-K37991163 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37645 BRD-K37991163 ASC 10 uM 24 h 0.0 0.0 0.0 -0.24 -0.82 0.15
37898 BRD-K37991163 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
91328 BRD-K37991163 HUH7 10 uM 72 h 0.0 0.0 0.0 0.29 1.03 0.52
95341 BRD-K37991163 A549 10 uM 6 h 0.0 0.0 0.0 0.31 1.1 0.69
95377 BRD-K37991163 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95407 BRD-K37991163 U2OS 10 uM 24 h -0.32 -1.32 0.83 0.0 0.0 0.0
123393 BRD-K37991163 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.35 1.25 1.29
123450 BRD-K37991163 THP1 10 uM 24 h -0.28 -1.18 0.5 0.0 0.0 0.0
123485 BRD-K37991163 YAPC 10 uM 24 h 0.22 0.93 0.05 0.0 0.0 0.0
131617 BRD-K37991163 HEK293 0.25 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 1.0
131652 BRD-K37991163 HELA 0.03 uM 24 h 0.2 0.81 0.0 0.2 0.7 0.02
131680 BRD-K37991163 HT29 2.22 uM 24 h 0.27 1.12 0.28 0.0 0.0 0.0
131710 BRD-K37991163 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131763 BRD-K37991163 JURKAT 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131814 BRD-K37991163 MCF10A 0.03 uM 24 h 0.0 0.0 0.0 0.32 1.12 0.77
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).