CMap Candidate Details

Structure:
CMap ID: C01456
Pert ID: BRD-A61304759
Compound Name: tanespimycin
Targets: HSP90AA1
MoA: HSP inhibitor
SMILES: COC1CC(C)CC2=C(NCC=C)C(=O)C=C(NC(=O)C(C)=CC=CC(OC)C(OC(N)=O)C(C)=CC(C)C1O)C2=O
InchiKey: AYUNIORJHRXIBJ-ZGQRYRSUSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5 BRD-A61304759 NCIH2073 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
13 BRD-A61304759 NCIH508 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.73 0.04
22 BRD-A61304759 NCIH596 10 uM 24 h 0.23 0.96 0.08 0.0 0.0 0.0
30 BRD-A61304759 SKBR3 0.66 uM 3 h 0.0 0.0 0.0 -0.2 -0.67 0.02
1138 BRD-A61304759 PC3 0.37 uM 6 h 0.32 1.33 0.84 0.0 0.0 0.0
87000 BRD-A61304759 HT29 20 uM 24 h 0.0 0.0 0.0 0.27 0.96 0.34
87299 BRD-A61304759 BJAB 10 uM 3 h 0.0 0.0 0.0 0.0 0.0 0.0
87350 BRD-A61304759 HBL1 10 uM 24 h -0.26 -1.09 0.33 -0.26 -0.87 0.22
87400 BRD-A61304759 K562 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87447 BRD-A61304759 KMS34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87500 BRD-A61304759 MINO 10 uM 3 h -0.18 -0.75 0.0 0.0 0.0 0.0
87551 BRD-A61304759 NALM6 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.14
87602 BRD-A61304759 OCILY10 2.5 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87652 BRD-A61304759 OCILY19 0.66 uM 24 h 0.0 0.0 0.0 0.23 0.82 0.1
87704 BRD-A61304759 OCILY3 2.5 uM 24 h 0.0 0.0 0.0 -0.28 -0.93 0.35
87751 BRD-A61304759 SKMEL5 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
87800 BRD-A61304759 THP1 2.5 uM 3 h 0.0 0.0 0.0 0.27 0.95 0.32
87831 BRD-A61304759 TMD8 0.66 uM 24 h 0.0 0.0 0.0 0.2 0.7 0.02
90283 BRD-A61304759 VCAP 10 uM 24 h -0.23 -0.98 0.12 0.0 0.0 0.0
90438 BRD-A61304759 HL60 10 uM 2 h 0.0 0.0 0.0 -0.25 -0.84 0.17
90645 BRD-A61304759 HCT116 0.04 uM 24 h 0.26 1.08 0.22 0.0 0.0 0.0
90675 BRD-A61304759 MCF10A 0.04 uM 24 h -0.15 -0.62 0.0 0.0 0.0 0.0
92858 BRD-A61304759 A375 10 uM 24 h 0.0 0.0 0.0 0.34 1.21 1.14
93026 BRD-A61304759 HA1E 10 uM 24 h -0.21 -0.88 0.03 0.0 0.0 0.0
93059 BRD-A61304759 HEK293 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93195 BRD-A61304759 HUVEC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93252 BRD-A61304759 JURKAT 10 uM 24 h -0.31 -1.31 0.82 0.0 0.0 0.0
93338 BRD-A61304759 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.18
93501 BRD-A61304759 SKL 10 uM 24 h -0.18 -0.74 0.0 0.27 0.96 0.34
93566 BRD-A61304759 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93677 BRD-A61304759 ASC 10 uM 24 h 0.27 1.11 0.26 0.0 0.0 0.0
93689 BRD-A61304759 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94080 BRD-A61304759 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94167 BRD-A61304759 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94211 BRD-A61304759 SHSY5Y 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94430 BRD-A61304759 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94667 BRD-A61304759 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
94715 BRD-A61304759 HME1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
97959 BRD-A61304759 P1A82 4 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99266 BRD-A61304759 U2OS 20 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
118787 BRD-A61304759 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118828 BRD-A61304759 HEPG2 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
118914 BRD-A61304759 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).