CMap Candidate Details

Structure:
CMap ID: C14563
Pert ID: BRD-K38183498
Compound Name: clonazepam
Targets: GABRA1; GABRA2; GABRA3; GABRA4; GABRA5; GABRA6; GABRB1; GABRB2; GABRB3; GABRD; GABRE; GABRG1; GABRG2; GABRG3; GABRP; GABRQ
MoA: GABA benzodiazepine site receptor agonist
SMILES: [O-][N+](=O)c1ccc2NC(=O)CN=C(c3ccccc3Cl)c2c1
InchiKey: DGBIGWXXNGSACT-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1418 BRD-K38183498 NPC 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123227 BRD-K38183498 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123273 BRD-K38183498 HA1E 10 uM 24 h 0.21 0.87 0.01 0.0 0.0 0.0
123306 BRD-K38183498 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123334 BRD-K38183498 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123361 BRD-K38183498 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123379 BRD-K38183498 MCF??7.00 10 uM 24 h 0.25 1.06 0.18 0.0 0.0 0.0
123415 BRD-K38183498 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123486 BRD-K38183498 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131540 BRD-K38183498 A549 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131618 BRD-K38183498 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131711 BRD-K38183498 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131764 BRD-K38183498 JURKAT 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131882 BRD-K38183498 MDAMB231 2.22 uM 24 h 0.29 1.2 0.43 -0.25 -0.84 0.18
131928 BRD-K38183498 THP1 0.08 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).