CMap Candidate Details

Structure:
CMap ID: C14584
Pert ID: BRD-K38251852
Compound Name: paxilline
Targets: KCNMA1
MoA: Potassium channel blocker
SMILES: CC(C)(O)[C@H]1O[C@H]2CC[C@]3(C)[C@]4(C)[C@H](Cc5c4[nH]c6ccccc56)CC[C@@]3(O)C2=CC1=O
InchiKey: ACNHBCIZLNNLRS-UBGQALKQSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
6877 BRD-K38251852 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7312 BRD-K38251852 HA1E 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.32
7648 BRD-K38251852 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
7859 BRD-K38251852 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
8283 BRD-K38251852 MCF??7.00 10 uM 6 h -0.25 -1.03 0.19 0.3 1.08 0.65
8364 BRD-K38251852 PC3 10 uM 24 h 0.0 0.0 0.0 0.3 1.07 0.63
8667 BRD-K38251852 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
96140 BRD-K38251852 A549 10 uM 24 h -0.29 -1.19 0.53 0.26 0.94 0.28
98755 BRD-K38251852 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99035 BRD-K38251852 NEU 10 uM 6 h 0.18 0.75 0.0 -0.31 -1.06 0.73
99910 BRD-K38251852 U2OS 12 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).