CMap Candidate Details

Structure:
CMap ID: C14601
Pert ID: BRD-K38305202
Compound Name: domperidone
Targets: DRD2; DRD3
MoA: Dopamine receptor antagonist
SMILES: Clc1ccc2n(C3CCN(CCCn4c5ccccc5[nH]c4=O)CC3)c(=O)[nH]c2c1
InchiKey: FGXWKSZFVQUSTL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5449 BRD-K38305202 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5619 BRD-K38305202 HCC515 10 uM 24 h 0.25 1.04 0.15 0.29 1.04 0.56
6187 BRD-K38305202 PC3 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.32 1.71
6320 BRD-K38305202 VCAP 10 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.2
37151 BRD-K38305202 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
37286 BRD-K38305202 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37648 BRD-K38305202 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
37900 BRD-K38305202 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38078 BRD-K38305202 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38200 BRD-K38305202 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
38473 BRD-K38305202 NPC 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.19 1.15
38715 BRD-K38305202 PHH 10 uM 24 h -0.28 -1.17 0.5 -0.23 -0.78 0.09
38948 BRD-K38305202 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90948 BRD-K38305202 HUH7 8 uM 72 h 0.0 0.0 0.0 -0.21 -0.71 0.03
99911 BRD-K38305202 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).