CMap Candidate Details

Structure:
CMap ID: C01461
Pert ID: BRD-A61599461
Compound Name: BRD-A61599461
Targets: TSHR
MoA: Thyroid-stimulating hormone receptor inverse agonist
SMILES: COc1ccc(cc1COc1c(C)cccc1C)C1Nc2ccccc2C(=O)N1Cc1cccnc1
InchiKey: ODFGSMOTQLYMHU-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
16184 BRD-A61599461 A375 10 uM 24 h 0.0 0.0 0.0 0.34 1.19 1.02
16870 BRD-A61599461 HCC515 10 uM 6 h 0.0 0.0 0.0 0.32 1.15 0.88
17196 BRD-A61599461 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.22 0.78 0.06
17535 BRD-A61599461 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
18106 BRD-A61599461 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
18209 BRD-A61599461 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
18547 BRD-A61599461 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).