CMap Candidate Details

Structure:
CMap ID: C01464
Pert ID: BRD-A61767428
Compound Name: ursolic-acid
Targets: HSD11B1; PTPN1
MoA: STAT inhibitor; ATPase inhibitor; Caspase inhibitor; HIV protease inhibitor; NFKB pathway inhibitor; Lipid peroxidase inhibitor; Steryl sulfatase inhibitor; Acetylcholinesterase inhibitor; Tyrosine phosphatase inhibitor; Quorum sensing signaling modulator; 11-beta hydroxysteroid dehydrogenase inhibitor
SMILES: C[C@@H]1C[C@H](C2CC[C@]3(C)C(=CC[C@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@H]2[C@@H]1C)C(O)=O
InchiKey: FZRIRHAXJWMMFP-PYQRESMBSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124587 BRD-A61767428 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124604 BRD-A61767428 A549 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.09 0.85
124674 BRD-A61767428 HELA 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124709 BRD-A61767428 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124736 BRD-A61767428 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 -0.24 -0.8 0.12
124770 BRD-A61767428 MCF??7.00 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124816 BRD-A61767428 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124858 BRD-A61767428 PC3 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132731 BRD-A61767428 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.34 -1.13 0.98
132772 BRD-A61767428 HEK293 0.03 uM 24 h 0.28 1.15 0.34 0.0 0.0 0.0
132887 BRD-A61767428 MCF10A 0.01 uM 24 h 0.0 0.0 0.0 0.32 1.14 0.87
132936 BRD-A61767428 THP1 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132968 BRD-A61767428 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).