CMap Candidate Details

Structure:
CMap ID: C14644
Pert ID: BRD-K38473998
Compound Name: cilomilast
Targets: PDE4A; PDE4B; PDE4D
MoA: Phosphodiesterase inhibitor
SMILES: COc1ccc(cc1OC1CCCC1)C1(CCC(CC1)C(O)=O)C#N
InchiKey: CFBUZOUXXHZCFB-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
96774 BRD-K38473998 PC3 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.72 0.04
123230 BRD-K38473998 A375 3.33 uM 24 h 0.0 0.0 0.0 -0.23 -0.78 0.09
123286 BRD-K38473998 HEK293 3.33 uM 24 h -0.27 -1.13 0.4 0.0 0.0 0.0
123309 BRD-K38473998 HELA 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.91 0.31
123336 BRD-K38473998 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123362 BRD-K38473998 MCF10A 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123454 BRD-K38473998 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.3 1.06 0.58
123488 BRD-K38473998 YAPC 10 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
131544 BRD-K38473998 A549 0.74 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
131580 BRD-K38473998 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131716 BRD-K38473998 HUVEC 2.22 uM 24 h 0.0 0.0 0.0 -0.35 -1.18 1.15
131769 BRD-K38473998 JURKAT 0.25 uM 24 h 0.0 0.0 0.0 0.22 0.79 0.07
131849 BRD-K38473998 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131886 BRD-K38473998 MDAMB231 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).