CMap Candidate Details

Structure:
CMap ID: C01467
Pert ID: BRD-A61793559
Compound Name: metolazone
Targets: SLC12A3
MoA: Carbonic anhydrase inhibitor
SMILES: CC1Nc2cc(Cl)c(cc2C(=O)N1c1ccccc1C)S(N)(=O)=O
InchiKey: AQCHWTWZEMGIFD-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5535 BRD-A61793559 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
6476 BRD-A61793559 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44778 BRD-A61793559 ASC 10 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.59
45097 BRD-A61793559 HEPG2 10 uM 6 h -0.23 -0.96 0.1 0.21 0.75 0.04
45617 BRD-A61793559 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.37 1.31 1.59
45897 BRD-A61793559 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46214 BRD-A61793559 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46529 BRD-A61793559 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100250 BRD-A61793559 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
124584 BRD-A61793559 A375 0.125 uM 24 h -0.3 -1.25 0.69 0.0 0.0 0.0
124623 BRD-A61793559 HA1E 0.37 uM 24 h 0.0 0.0 0.0 -0.32 -1.08 0.79
124669 BRD-A61793559 HELA 0.37 uM 24 h 0.22 0.93 0.05 -0.26 -0.87 0.23
124703 BRD-A61793559 HT29 0.37 uM 24 h 0.24 0.99 0.1 -0.26 -0.88 0.24
124732 BRD-A61793559 JURKAT 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124809 BRD-A61793559 MDAMB231 1.11 uM 24 h 0.35 1.45 1.12 0.0 0.0 0.0
124852 BRD-A61793559 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132701 BRD-A61793559 A549 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132766 BRD-A61793559 HEK293 0.25 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.12
132880 BRD-A61793559 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 -0.29 -0.97 0.44
132934 BRD-A61793559 THP1 0.08 uM 24 h 0.3 1.27 0.58 0.0 0.0 0.0
132965 BRD-A61793559 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).