CMap Candidate Details
Structure:
| CMap ID: | C00147 |
| Pert ID: | BRD-A05821830 |
| Compound Name: | docetaxel |
| Targets: | TUBB |
| MoA: | Tubulin inhibitor |
| SMILES: | CC(=O)O[C@@]12CO[C@@H]1C[C@H](O)[C@]1(C)C2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)c3ccccc3)C(C)=C([C@@H](O)C1=O)C2(C)C |
| InchiKey: | ZDZOTLJHXYCWBA-JXHJHTFNSA-N |
| Compound Aliases: | -- |
| Score ID | Pert ID | Cell Line | Pert Dose | Pert Time | Raw Score (GSE126848) | Normalized Score (GSE126848) | fdr_q_nlog10 (GSE126848) | Raw Score (GSE135251) | Normalized Score (GSE135251) | fdr_q_nlog10 (GSE135251) |
|---|---|---|---|---|---|---|---|---|---|---|
| 122541 | BRD-A05821830 | A375 | 0.04 uM | 24 h | 0.25 | 1.05 | 0.17 | 0.0 | 0.0 | 0.0 |
| 122574 | BRD-A05821830 | A549 | 10 uM | 24 h | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 |
| 122714 | BRD-A05821830 | MCF10A | 0.04 uM | 24 h | 0.18 | 0.74 | 0.0 | -0.37 | -1.23 | 1.28 |
| 122770 | BRD-A05821830 | MDAMB231 | 0.125 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.38 | -1.29 | 1.53 |
| 130910 | BRD-A05821830 | HA1E | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.36 | -1.21 | 1.22 |
| 130932 | BRD-A05821830 | HEK293 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.39 | -1.3 | 1.68 |
| 130962 | BRD-A05821830 | HELA | 0.01 uM | 24 h | 0.27 | 1.14 | 0.32 | -0.34 | -1.15 | 1.07 |
| 130995 | BRD-A05821830 | HT29 | 0.01 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.37 | -1.23 | 1.28 |
| 131036 | BRD-A05821830 | HUVEC | 0.08 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.34 | -1.15 | 1.07 |
| 131080 | BRD-A05821830 | MCF??7.00 | 0.08 uM | 24 h | -0.24 | -1.01 | 0.17 | -0.33 | -1.12 | 0.93 |
| 131147 | BRD-A05821830 | PC3 | 2.22 uM | 24 h | 0.0 | 0.0 | 0.0 | -0.38 | -1.28 | 1.45 |
| 131180 | BRD-A05821830 | YAPC | 0.25 uM | 24 h | -0.21 | -0.89 | 0.04 | 0.0 | 0.0 | 0.0 |