CMap Candidate Details

Structure:
CMap ID: C14740
Pert ID: BRD-K38744518
Compound Name: betulinic-acid
Targets: GPBAR1
MoA: Apoptosis stimulant; Caspase activator; NFkB pathway activator; HIV integrase inhibitor; Topoisomerase inhibitor; Diacylglycerol O acyltransferase inhibitor; SARS coronavirus 3C-like protease inhibitor
SMILES: CC(=C)[C@@H]1CC[C@@]2(CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@@]34C)[C@H]12)C(O)=O
InchiKey: QGJZLNKBHJESQX-XNWPAUOFSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123224 BRD-K38744518 A375 10 uM 24 h -0.22 -0.9 0.04 0.19 0.66 0.01
123302 BRD-K38744518 HELA 3.33 uM 24 h -0.23 -0.96 0.09 0.0 0.0 0.0
123331 BRD-K38744518 HT29 0.37 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123389 BRD-K38744518 MDAMB231 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123447 BRD-K38744518 THP1 3.33 uM 24 h 0.0 0.0 0.0 -0.33 -1.09 0.85
123481 BRD-K38744518 YAPC 10 uM 24 h 0.0 0.0 0.0 0.35 1.24 1.27
131537 BRD-K38744518 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131573 BRD-K38744518 HA1E 2.22 uM 24 h 0.0 0.0 0.0 -0.27 -0.9 0.28
131610 BRD-K38744518 HEK293 0.03 uM 24 h -0.18 -0.75 0.0 0.0 0.0 0.0
131703 BRD-K38744518 HUVEC 0.08 uM 24 h 0.24 0.98 0.09 0.0 0.0 0.0
131756 BRD-K38744518 JURKAT 0.01 uM 24 h -0.25 -1.03 0.2 0.0 0.0 0.0
131811 BRD-K38744518 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.31 1.11 0.72
131840 BRD-K38744518 MCF??7.00 0.08 uM 24 h 0.19 0.77 0.0 0.0 0.0 0.0
131911 BRD-K38744518 PC3 0.01 uM 24 h -0.26 -1.1 0.34 -0.35 -1.16 1.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).