CMap Candidate Details

Structure:
CMap ID: C14749
Pert ID: BRD-K38775274
Compound Name: dexamethasone
Targets: NR3C1
MoA: Glucocorticoid receptor agonist
SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO
InchiKey: UREBDLICKHMUKA-CXSFZGCWSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
33615 BRD-K38775274 A375 10 uM 6 h 0.21 0.88 0.02 0.0 0.0 0.0
33805 BRD-K38775274 A549 10 uM 24 h 0.0 0.0 0.0 -0.27 -0.92 0.33
34098 BRD-K38775274 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
34615 BRD-K38775274 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.03 0.62
35143 BRD-K38775274 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
35317 BRD-K38775274 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
36260 BRD-K38775274 PHH 10 uM 24 h -0.3 -1.25 0.7 0.0 0.0 0.0
36557 BRD-K38775274 SKB 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.85 0.2
36965 BRD-K38775274 VCAP 10 uM 6 h 0.28 1.16 0.36 -0.3 -1.02 0.6
50181 BRD-K38775274 HA1E 10 uM 6 h 0.0 0.0 0.0 -0.21 -0.71 0.04
50926 BRD-K38775274 PC3 10 uM 6 h 0.0 0.0 0.0 -0.43 -1.44 15.35
91149 BRD-K38775274 HUH7 8 uM 72 h 0.0 0.0 0.0 -0.24 -0.82 0.15
98808 BRD-K38775274 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
99037 BRD-K38775274 NEU 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.88 0.25
99917 BRD-K38775274 U2OS 12.5 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).