CMap Candidate Details

Structure:
CMap ID: C01475
Pert ID: BRD-A62025033
Compound Name: temsirolimus
Targets: MTOR
MoA: MTOR inhibitor
SMILES: COC1CC(CC(C)C2CC(=O)C(C)C=C(C)C(O)C(OC)C(=O)C(C)CC(C)C=CC=CC=C(C)C(CC3CCC(C)C(O)(O3)C(=O)C(=O)N3CCCCC3C(=O)O2)OC)CCC1OC(=O)C(C)(CO)CO
InchiKey: CBPNZQVSJQDFBE-WEDGMEQVSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
9298 BRD-A62025033 AGS 10 uM 6 h -0.19 -0.8 0.0 0.0 0.0 0.0
9602 BRD-A62025033 H1299 10 uM 6 h 0.21 0.86 0.01 0.0 0.0 0.0
10011 BRD-A62025033 HA1E 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10222 BRD-A62025033 HCC515 10 uM 24 h 0.0 0.0 0.0 0.25 0.9 0.22
10409 BRD-A62025033 HCT116 10 uM 6 h 0.0 0.0 0.0 0.27 0.94 0.29
10677 BRD-A62025033 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.25 -0.83 0.17
11350 BRD-A62025033 NCIH2073 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11663 BRD-A62025033 NCIH508 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
11922 BRD-A62025033 NCIH596 10 uM 6 h -0.24 -1.0 0.14 -0.25 -0.85 0.19
12213 BRD-A62025033 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12674 BRD-A62025033 SW480 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13541 BRD-A62025033 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
95414 BRD-A62025033 U2OS 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.31 1.71
96052 BRD-A62025033 PHH 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126028 BRD-A62025033 HELA 1.11 uM 24 h -0.2 -0.84 0.01 0.0 0.0 0.0
126119 BRD-A62025033 JURKAT 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126172 BRD-A62025033 MCF10A 10 uM 24 h -0.24 -1.0 0.15 0.0 0.0 0.0
126236 BRD-A62025033 MDAMB231 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126258 BRD-A62025033 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
126291 BRD-A62025033 THP1 10 uM 24 h 0.0 0.0 0.0 -0.33 -1.11 0.92
134001 BRD-A62025033 A375 0.74 uM 24 h -0.17 -0.72 0.0 -0.32 -1.07 0.76
134032 BRD-A62025033 A549 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134093 BRD-A62025033 HEK293 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
134177 BRD-A62025033 HT29 0.08 uM 24 h 0.0 0.0 0.0 0.19 0.68 0.01
134205 BRD-A62025033 HUVEC 2.22 uM 24 h 0.17 0.72 0.0 -0.25 -0.86 0.21
134224 BRD-A62025033 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.25 0.89 0.21
134308 BRD-A62025033 YAPC 0.74 uM 24 h -0.22 -0.9 0.04 -0.35 -1.16 1.11
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).