CMap Candidate Details

Structure:
CMap ID: C01476
Pert ID: BRD-A62035778
Compound Name: scopolamine
Targets: CHRM1; CHRM2; CHRM3; CHRM4
MoA: Acetylcholine receptor antagonist
SMILES: CN1C2C[C@@H](C[C@H]1[C@H]1OC21)OC(=O)[C@H](CO)c1ccccc1
InchiKey: STECJAGHUSJQJN-WLQVYHSDSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
4527 BRD-A62035778 HCC515 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.87 0.22
4861 BRD-A62035778 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.35 -1.17 1.11
37528 BRD-A62035778 ASC 10 uM 24 h -0.26 -1.1 0.35 0.0 0.0 0.0
37837 BRD-A62035778 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
38375 BRD-A62035778 NPC 10 uM 24 h 0.27 1.13 0.29 0.0 0.0 0.0
38877 BRD-A62035778 SKB 10 uM 24 h -0.21 -0.87 0.02 0.0 0.0 0.0
124926 BRD-A62035778 A375 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
124951 BRD-A62035778 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125044 BRD-A62035778 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125099 BRD-A62035778 MDAMB231 0.04 uM 24 h -0.29 -1.22 0.62 -0.36 -1.22 1.25
125142 BRD-A62035778 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.36
125193 BRD-A62035778 YAPC 0.04 uM 24 h 0.19 0.81 0.0 0.0 0.0 0.0
133004 BRD-A62035778 HA1E 0.25 uM 24 h 0.22 0.92 0.04 -0.27 -0.89 0.27
133028 BRD-A62035778 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133082 BRD-A62035778 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.24 0.84 0.13
133187 BRD-A62035778 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.25 0.88 0.19
133213 BRD-A62035778 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.37 1.3 1.59
133277 BRD-A62035778 PC3 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).