CMap Candidate Details

Structure:
CMap ID: C01479
Pert ID: BRD-A62182663
Compound Name: YK-4279
Targets: DHX9; FLI1
MoA: Apoptosis stimulant; Binding of RNA helicase A to the transcription factor EWS-FLI1 inhibitor
SMILES: COc1ccc(cc1)C(=O)CC1(O)C(=O)Nc2c1c(Cl)ccc2Cl
InchiKey: HLXSCTYHLQHQDJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
8879 BRD-A62182663 A375 10 uM 24 h 0.0 0.0 0.0 -0.39 -1.3 1.59
9149 BRD-A62182663 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9299 BRD-A62182663 AGS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
9603 BRD-A62182663 H1299 10 uM 6 h 0.0 0.0 0.0 -0.28 -0.94 0.37
9883 BRD-A62182663 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
10126 BRD-A62182663 HCC515 10 uM 24 h -0.25 -1.05 0.24 -0.21 -0.69 0.02
10410 BRD-A62182663 HCT116 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
10678 BRD-A62182663 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.34 -1.14 1.03
10910 BRD-A62182663 HT29 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11140 BRD-A62182663 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
11351 BRD-A62182663 NCIH2073 10 uM 6 h -0.24 -1.01 0.16 -0.26 -0.88 0.24
11923 BRD-A62182663 NCIH596 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.45
12214 BRD-A62182663 NOMO1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
12442 BRD-A62182663 PC3 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.21 1.24
12675 BRD-A62182663 SW480 10 uM 6 h -0.22 -0.92 0.06 0.0 0.0 0.0
12944 BRD-A62182663 THP1 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
13158 BRD-A62182663 U937 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.45
88414 BRD-A62182663 VCAP 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).