CMap Candidate Details

Structure:
CMap ID: C01484
Pert ID: BRD-A62336480
Compound Name: niguldipine
Targets: ADRA1A; CACNA1C
MoA: Calcium channel blocker; Adrenergic receptor antagonist
SMILES: COC(=O)C1=C(C)NC(=C(C1c2cccc(c2)[N+](=O)[O-])C(=O)OCCCN3CCC(CC3)(c4ccccc4)c5ccccc5)C
InchiKey: SVJMLYUFVDMUHP-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2813 BRD-A62336480 HA1E 10 uM 24 h 0.24 1.0 0.1 -0.27 -0.91 0.3
3112 BRD-A62336480 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3447 BRD-A62336480 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3696 BRD-A62336480 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41681 BRD-A62336480 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
41887 BRD-A62336480 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42225 BRD-A62336480 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
42567 BRD-A62336480 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
42872 BRD-A62336480 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
43133 BRD-A62336480 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.25 -0.86 0.2
43734 BRD-A62336480 PHH 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91040 BRD-A62336480 HUH7 6.66 uM 72 h -0.24 -1.0 0.15 -0.23 -0.78 0.1
98844 BRD-A62336480 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99201 BRD-A62336480 NPC 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).