CMap Candidate Details

Structure:
CMap ID: C14931
Pert ID: BRD-K39339537
Compound Name: epirizole
Targets: PTGS1; PTGS2
MoA: Cyclooxygenase inhibitor
SMILES: COc1cc(C)nn1-c1nc(C)cc(OC)n1
InchiKey: RHAXSHUQNIEUEY-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
3194 BRD-K39339537 HCC515 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
3789 BRD-K39339537 VCAP 10 uM 24 h 0.24 1.0 0.11 0.23 0.8 0.08
22285 BRD-K39339537 A549 10 uM 6 h -0.29 -1.23 0.62 -0.3 -0.99 0.51
44952 BRD-K39339537 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45247 BRD-K39339537 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.24 0.85 0.14
46069 BRD-K39339537 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46704 BRD-K39339537 SKB 10 uM 24 h 0.0 0.0 0.0 -0.36 -1.22 1.25
123229 BRD-K39339537 A375 0.125 uM 24 h -0.27 -1.12 0.39 -0.27 -0.9 0.28
123308 BRD-K39339537 HELA 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123335 BRD-K39339537 HT29 0.04 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.41
131579 BRD-K39339537 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131621 BRD-K39339537 HEK293 2.22 uM 24 h 0.0 0.0 0.0 -0.36 -1.2 1.22
131715 BRD-K39339537 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131768 BRD-K39339537 JURKAT 2.22 uM 24 h 0.19 0.79 0.0 -0.34 -1.14 1.05
131818 BRD-K39339537 MCF10A 2.22 uM 24 h -0.27 -1.12 0.38 0.3 1.05 0.58
131848 BRD-K39339537 MCF??7.00 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131885 BRD-K39339537 MDAMB231 0.25 uM 24 h -0.27 -1.14 0.42 0.0 0.0 0.0
131914 BRD-K39339537 PC3 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131929 BRD-K39339537 THP1 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131950 BRD-K39339537 YAPC 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).