CMap Candidate Details

Structure:
CMap ID: C01499
Pert ID: BRD-A62879835
Compound Name: rifaximin
Targets: NR1I2
MoA: RNA synthesis inhibitor
SMILES: CO[C@H]1C=CO[C@@]2(C)Oc3c(C2=O)c2c4nc5cc(C)ccn5c4c(NC(=O)C(C)=C/C=C/[C@H](C)[C@H](O)[C@@H](C)C(O)[C@@H](C)[C@H](OC(C)=O)[C@@H]1C)c(O)c2c(O)c3C
InchiKey: NZCRJKRKKOLAOJ-HQDKJBBOSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124685 BRD-A62879835 HT29 3.33 uM 24 h 0.0 0.0 0.0 -0.21 -0.72 0.04
124719 BRD-A62879835 JURKAT 10 uM 24 h -0.26 -1.1 0.33 0.18 0.63 0.0
124788 BRD-A62879835 MDAMB231 0.04 uM 24 h -0.24 -1.02 0.18 0.0 0.0 0.0
124831 BRD-A62879835 PC3 0.125 uM 24 h 0.26 1.07 0.2 -0.41 -1.39 2.02
124872 BRD-A62879835 THP1 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132658 BRD-A62879835 A375 2.22 uM 24 h 0.0 0.0 0.0 -0.31 -1.04 0.67
132683 BRD-A62879835 A549 0.25 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132716 BRD-A62879835 HA1E 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132745 BRD-A62879835 HEK293 0.25 uM 24 h 0.0 0.0 0.0 0.36 1.28 1.37
132784 BRD-A62879835 HELA 0.01 uM 24 h -0.26 -1.09 0.33 0.0 0.0 0.0
132863 BRD-A62879835 MCF10A 0.74 uM 24 h 0.3 1.26 0.56 0.0 0.0 0.0
132895 BRD-A62879835 MCF??7.00 0.01 uM 24 h 0.23 0.96 0.08 0.0 0.0 0.0
132946 BRD-A62879835 YAPC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).