CMap Candidate Details

Structure:
CMap ID: C15065
Pert ID: BRD-K39746403
Compound Name: erythromycin-estolate
Targets: CYP3A4; CYP51A1; ALB; MLNR; KCNH2; ABCB1; SLC47A1
MoA: Bacterial 50S ribosomal subunit inhibitor
SMILES: CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2OC(=O)CC)N(C)C)[C@](C)(O)C[C@@H](C)C(=O)[C@H](C)[C@@H](O)[C@]1(C)O
InchiKey: TYQXKHPOXXXCTP-CSLYCKPJSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5452 BRD-K39746403 HA1E 10 uM 6 h -0.22 -0.93 0.07 0.25 0.89 0.2
5624 BRD-K39746403 HCC515 10 uM 24 h 0.0 0.0 0.0 0.31 1.1 0.68
5910 BRD-K39746403 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.26 -0.87 0.23
6023 BRD-K39746403 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6277 BRD-K39746403 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6545 BRD-K39746403 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39135 BRD-K39746403 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39451 BRD-K39746403 A549 10 uM 6 h 0.22 0.91 0.04 0.4 1.42 2.19
39696 BRD-K39746403 ASC 10 uM 24 h 0.18 0.76 0.0 0.28 0.99 0.4
40472 BRD-K39746403 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40813 BRD-K39746403 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41117 BRD-K39746403 NPC 10 uM 24 h -0.19 -0.78 0.0 -0.32 -1.07 0.76
41452 BRD-K39746403 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99926 BRD-K39746403 U2OS 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).