CMap Candidate Details

Structure:
CMap ID: C01507
Pert ID: BRD-A63346720
Compound Name: rimcazole
Targets: SIGMAR1
MoA: Sigma receptor antagonist
SMILES: CC1CN(CCCn2c3ccccc3c4ccccc24)CC(C)N1
InchiKey: GUDVQJXODNJRIJ-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
1700 BRD-A63346720 HA1E 10 uM 6 h -0.21 -0.87 0.02 0.0 0.0 0.0
1837 BRD-A63346720 HCC515 10 uM 24 h 0.0 0.0 0.0 0.36 1.26 1.29
2346 BRD-A63346720 PC3 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
2580 BRD-A63346720 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39054 BRD-A63346720 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39276 BRD-A63346720 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39577 BRD-A63346720 ASC 10 uM 24 h 0.23 0.97 0.08 0.0 0.0 0.0
39902 BRD-A63346720 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.3 1.05 0.56
40186 BRD-A63346720 HT29 10 uM 6 h 0.21 0.86 0.01 0.0 0.0 0.0
40431 BRD-A63346720 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.36 1.26 1.29
40704 BRD-A63346720 NEU 10 uM 24 h -0.2 -0.83 0.0 0.0 0.0 0.0
41003 BRD-A63346720 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
100258 BRD-A63346720 U2OS 10 uM 6 h 0.0 0.0 0.0 0.26 0.94 0.28
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).