CMap Candidate Details

Structure:
CMap ID: C15114
Pert ID: BRD-K39915878
Compound Name: loxapine
Targets: DRD1; DRD2; DRD3; DRD4; HRH1; HTR2A; HTR2C; HTR6
MoA: Dopamine receptor antagonist; Serotonin receptor antagonist
SMILES: CN1CCN(CC1)C1=Nc2ccccc2Oc2ccc(Cl)cc12
InchiKey: XJGVXQDUIWGIRW-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
5326 BRD-K39915878 HA1E 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
5773 BRD-K39915878 HCC515 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
5911 BRD-K39915878 HEPG2 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6094 BRD-K39915878 MCF??7.00 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
6546 BRD-K39915878 VCAP 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
39136 BRD-K39915878 A375 10 uM 6 h 0.0 0.0 0.0 0.28 0.99 0.4
39326 BRD-K39915878 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
39697 BRD-K39915878 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
40277 BRD-K39915878 HT29 10 uM 6 h 0.0 0.0 0.0 -0.29 -0.97 0.46
40814 BRD-K39915878 NEU 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41118 BRD-K39915878 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
41453 BRD-K39915878 SKB 10 uM 24 h 0.0 0.0 0.0 -0.28 -0.95 0.4
51465 BRD-K39915878 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
99927 BRD-K39915878 U2OS 10 uM 6 h -0.29 -1.21 0.59 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).