CMap Candidate Details

Structure:
CMap ID: C15128
Pert ID: BRD-K39974922
Compound Name: lenvatinib
Targets: FLT4; KDR; KIT; FGFR1; FLT1
MoA: FGFR inhibitor; KIT inhibitor; PDGFR inhibitor; VEGFR inhibitor
SMILES: COc1cc2nccc(Oc3ccc(NC(=O)NC4CC4)c(Cl)c3)c2cc1C(N)=O
InchiKey: WOSKHXYHFSIKNG-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123232 BRD-K39974922 A375 10 uM 24 h 0.0 0.0 0.0 0.26 0.93 0.27
123261 BRD-K39974922 A549 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123337 BRD-K39974922 HT29 10 uM 24 h 0.23 0.97 0.08 -0.3 -1.0 0.55
123364 BRD-K39974922 MCF10A 10 uM 24 h 0.0 0.0 0.0 -0.34 -1.15 1.05
123418 BRD-K39974922 PC3 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123455 BRD-K39974922 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123491 BRD-K39974922 YAPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131583 BRD-K39974922 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131623 BRD-K39974922 HEK293 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131657 BRD-K39974922 HELA 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131719 BRD-K39974922 HUVEC 2.22 uM 24 h -0.3 -1.24 0.64 0.0 0.0 0.0
131772 BRD-K39974922 JURKAT 0.08 uM 24 h -0.21 -0.86 0.02 0.31 1.11 0.73
131852 BRD-K39974922 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131888 BRD-K39974922 MDAMB231 2.22 uM 24 h 0.0 0.0 0.0 -0.28 -0.94 0.38
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).