CMap Candidate Details

Structure:
CMap ID: C01521
Pert ID: BRD-A63752151
Compound Name: fidarestat
Targets: AKR1B1
MoA: Aldose reductase inhibitor
SMILES: NC(=O)C1CC2(NC(=O)NC2=O)c2cc(F)ccc2O1
InchiKey: WAAPEIZFCHNLKK-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124937 BRD-A63752151 A375 3.33 uM 24 h -0.22 -0.91 0.05 -0.27 -0.92 0.34
124965 BRD-A63752151 A549 0.37 uM 24 h -0.24 -1.01 0.17 -0.31 -1.04 0.67
125026 BRD-A63752151 HELA 3.33 uM 24 h 0.26 1.08 0.21 0.0 0.0 0.0
125096 BRD-A63752151 MCF??7.00 0.37 uM 24 h -0.23 -0.94 0.08 0.0 0.0 0.0
125163 BRD-A63752151 THP1 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125207 BRD-A63752151 YAPC 1.11 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.49
133014 BRD-A63752151 HA1E 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133049 BRD-A63752151 HEK293 0.25 uM 24 h -0.23 -0.97 0.11 0.3 1.06 0.6
133117 BRD-A63752151 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133156 BRD-A63752151 JURKAT 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133197 BRD-A63752151 MCF10A 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133261 BRD-A63752151 MDAMB231 0.01 uM 24 h 0.0 0.0 0.0 0.28 0.98 0.38
133292 BRD-A63752151 PC3 0.03 uM 24 h 0.28 1.19 0.41 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).