CMap Candidate Details

Structure:
CMap ID: C15381
Pert ID: BRD-K40738845
Compound Name: BMS-777607
Targets: MERTK; MET; MST1R; AXL; TYRO3
MoA: FLT3 inhibitor; C-Met inhibitor; AXL kinase inhibitor; Macrophage inhibitor; Tyrosine kinase inhibitor; Hepatocyte growth factor receptor inhibitor
SMILES: CCOc1ccn(-c2ccc(F)cc2)c(=O)c1C(=O)Nc1ccc(Oc2ccnc(N)c2Cl)c(F)c1
InchiKey: VNBRGSXVFBYQNN-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
90864 BRD-K40738845 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
91803 BRD-K40738845 HS578T 2.22 uM 6 h 0.0 0.0 0.0 -0.29 -0.96 0.44
91935 BRD-K40738845 SKBR3 0.08 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
92958 BRD-K40738845 ASC 10 uM 24 h 0.2 0.83 0.0 0.0 0.0 0.0
93004 BRD-K40738845 CD34 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93177 BRD-K40738845 HEPG2 0.12 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93230 BRD-K40738845 HUVEC 3.33 uM 24 h -0.22 -0.91 0.06 0.21 0.76 0.05
93364 BRD-K40738845 MDAMB231 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
93422 BRD-K40738845 NPC 10 uM 24 h 0.26 1.07 0.19 -0.23 -0.79 0.1
93451 BRD-K40738845 PC3 10 uM 24 h 0.0 0.0 0.0 -0.29 -0.98 0.49
93490 BRD-K40738845 SKL 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123289 BRD-K40738845 HEK293 0.04 uM 24 h 0.0 0.0 0.0 -0.38 -1.28 1.45
123458 BRD-K40738845 THP1 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131526 BRD-K40738845 A375 2.22 uM 24 h 0.0 0.0 0.0 -0.38 -1.27 1.39
131551 BRD-K40738845 A549 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131585 BRD-K40738845 HA1E 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131659 BRD-K40738845 HELA 0.74 uM 24 h 0.25 1.03 0.14 0.0 0.0 0.0
131686 BRD-K40738845 HT29 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131777 BRD-K40738845 JURKAT 0.74 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131856 BRD-K40738845 MCF??7.00 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131953 BRD-K40738845 YAPC 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).