CMap Candidate Details

Structure:
CMap ID: C15386
Pert ID: BRD-K40758068
Compound Name: efavirenz
Targets: CYP1A2; CYP2B6; CYP2C19; CYP2C9; CYP2D6; CYP3A4
MoA: HIV protease inhibitor
SMILES: FC(F)(F)[C@]1(OC(=O)Nc2ccc(Cl)cc12)C#CC1CC1
InchiKey: XPOQHMRABVBWPR-ZDUSSCGKSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
25366 BRD-K40758068 VCAP 10 uM 24 h 0.0 0.0 0.0 -0.31 -1.03 0.63
91454 BRD-K40758068 HUH7 10 uM 72 h 0.0 0.0 0.0 -0.33 -1.1 0.86
97183 BRD-K40758068 PC3 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
123233 BRD-K40758068 A375 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123275 BRD-K40758068 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123288 BRD-K40758068 HEK293 10 uM 24 h 0.0 0.0 0.0 -0.26 -0.88 0.24
123339 BRD-K40758068 HT29 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123457 BRD-K40758068 THP1 0.125 uM 24 h -0.21 -0.89 0.04 -0.32 -1.08 0.78
123493 BRD-K40758068 YAPC 0.04 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131548 BRD-K40758068 A549 0.08 uM 24 h -0.23 -0.97 0.1 -0.28 -0.95 0.4
131658 BRD-K40758068 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131721 BRD-K40758068 HUVEC 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131774 BRD-K40758068 JURKAT 0.01 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
131821 BRD-K40758068 MCF10A 0.74 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.23
131853 BRD-K40758068 MCF??7.00 0.01 uM 24 h 0.28 1.17 0.38 -0.3 -1.0 0.52
131890 BRD-K40758068 MDAMB231 2.22 uM 24 h -0.23 -0.96 0.1 0.3 1.06 0.58
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).