CMap Candidate Details

Structure:
CMap ID: C01539
Pert ID: BRD-A64290322
Compound Name: cyclosporin-a
Targets: PPIA; PPP3CA
MoA: Calcineurin inhibitor
SMILES: CCC1NC(=O)C(C(O)C(C)CC=CC)N(C)C(=O)C(C(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(CC(C)C)N(C)C(=O)C(C)NC(=O)C(C)NC(=O)C(CC(C)C)N(C)C(=O)C(NC(=O)C(CC(C)C)N(C)C(=O)CN(C)C1=O)C(C)C
InchiKey: PMATZTZNYRCHOR-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
2815 BRD-A64290322 HA1E 10 uM 24 h 0.22 0.92 0.04 0.33 1.18 1.0
3114 BRD-A64290322 HCC515 10 uM 24 h 0.0 0.0 0.0 0.25 0.87 0.17
3448 BRD-A64290322 PC3 10 uM 24 h 0.0 0.0 0.0 0.21 0.76 0.05
3697 BRD-A64290322 VCAP 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
44254 BRD-A64290322 A375 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44649 BRD-A64290322 A549 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
44780 BRD-A64290322 ASC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
45099 BRD-A64290322 HEPG2 10 uM 6 h 0.0 0.0 0.0 -0.31 -1.03 0.64
45371 BRD-A64290322 HT29 10 uM 6 h 0.0 0.0 0.0 0.0 0.0 0.0
45619 BRD-A64290322 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 -0.22 -0.75 0.06
45899 BRD-A64290322 NPC 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
46216 BRD-A64290322 PHH 10 uM 24 h 0.0 0.0 0.0 0.23 0.81 0.09
46530 BRD-A64290322 SKB 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
90907 BRD-A64290322 HUH7 2.5 uM 72 h 0.24 0.99 0.1 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).