CMap Candidate Details

Structure:
CMap ID: C15394
Pert ID: BRD-K40797222
Compound Name: SC-12267
Targets: DHODH; IL17A
MoA: Dihydroorotate dehydrogenase inhibitor
SMILES: COc1cccc(c1)-c1ccc(NC(=O)C2=C(CCC2)C(O)=O)c(F)c1
InchiKey: XPRDUGXOWVXZLL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
123547 BRD-K40797222 HA1E 1.11 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123599 BRD-K40797222 HEK293 10 uM 24 h 0.25 1.06 0.19 0.35 1.24 1.24
123631 BRD-K40797222 HELA 10 uM 24 h 0.0 0.0 0.0 0.4 1.43 2.2
123666 BRD-K40797222 HT29 3.33 uM 24 h -0.22 -0.92 0.06 0.34 1.2 1.12
123714 BRD-K40797222 MCF10A 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123734 BRD-K40797222 MCF??7.00 10 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
123751 BRD-K40797222 PC3 10 uM 24 h 0.0 0.0 0.0 0.26 0.91 0.24
123778 BRD-K40797222 YAPC 10 uM 24 h 0.0 0.0 0.0 -0.21 -0.72 0.04
131999 BRD-K40797222 A375 2.22 uM 24 h 0.26 1.07 0.2 0.0 0.0 0.0
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).