CMap Candidate Details

Structure:
CMap ID: C01542
Pert ID: BRD-A64406146
Compound Name: timofibrate
Targets: LPL
MoA: Cholesterol inhibitor; Lipase clearing factor inhibitor
SMILES: CC(C)(Oc1ccc(Cl)cc1)C(=O)N1CSCC1C(O)=O
InchiKey: QSNOWCXXECLALL-UHFFFAOYSA-N
Compound Aliases: --

Score ID Pert ID Cell Line Pert Dose Pert Time Raw Score (GSE126848) Normalized Score (GSE126848) fdr_q_nlog10 (GSE126848) Raw Score (GSE135251) Normalized Score (GSE135251) fdr_q_nlog10 (GSE135251)
124969 BRD-A64406146 A549 10 uM 24 h -0.26 -1.09 0.32 0.0 0.0 0.0
125001 BRD-A64406146 HA1E 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125077 BRD-A64406146 MCF10A 3.33 uM 24 h -0.23 -0.94 0.08 -0.26 -0.87 0.23
125114 BRD-A64406146 MDAMB231 0.37 uM 24 h -0.32 -1.34 0.98 0.0 0.0 0.0
125167 BRD-A64406146 THP1 3.33 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
125210 BRD-A64406146 YAPC 0.125 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
132980 BRD-A64406146 A375 0.74 uM 24 h 0.0 0.0 0.0 0.27 0.95 0.32
133054 BRD-A64406146 HEK293 0.01 uM 24 h 0.0 0.0 0.0 0.33 1.17 0.93
133091 BRD-A64406146 HELA 0.03 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133119 BRD-A64406146 HT29 0.01 uM 24 h 0.28 1.17 0.36 0.0 0.0 0.0
133161 BRD-A64406146 JURKAT 0.74 uM 24 h 0.21 0.86 0.01 0.0 0.0 0.0
133228 BRD-A64406146 MCF??7.00 2.22 uM 24 h 0.0 0.0 0.0 0.0 0.0 0.0
133294 BRD-A64406146 PC3 0.01 uM 24 h 0.25 1.06 0.19 -0.25 -0.84 0.18
The GSE89632 and GSE126848 datasets are hepatic gene expression profiles of nonalcoholic fatty liver disease (NAFLD).